FACTS ABOUT NAD+ DEFICIENCY SYMPTOMS AND TREATMENT REVEALED

Upcoming, we handled cells with different concentrations of NAD+. When extra for twenty-four h at 80 µM in HeLa and 400 µM in U2OS cells, NAD+ impaired the incorporation of EdU (Fig. 2a and Extended Info Fig. 1k,l). Furthermore, sixteen µM of NAD+ was enough to scale back fork pace by ~forty% in HeLa cells with out impacting the total vo